Launch architecture, retention design, and elite talent for advanced metabolic therapies
Five core services designed to de-risk your U.S. launch from strategy through execution. Each can stand alone or layer together into a comprehensive mandate.
De-Risking the U.S. Advanced Metabolic Launch
A concise audio overview of UEM's approach to launch architecture, retention design, and why emerging biotechs need a different playbook.
Advanced Metabolic Retention Audit
For biotechs with GLP-1, dual/triple agonists, or obesity therapies already in market or close to launch.
What We Do
Quantify revenue leakage from early discontinuation, access barriers, and channel friction using your data and emerging real-world persistence benchmarks.
Map your current patient journey from prescription to 6-12 month follow-up, highlighting friction points in titration, side-effect management, affordability, and channel.
Assess your HCP and KOL narrative vs. the evolving cardiometabolic evidence base and payer expectations.
Deliverables
Retention Leakage Report with financial model and prioritized list of 5-7 operational "leaks"
Retention Blueprint: lean retention engine design including patient support, nurse/liaison model, loyalty architecture, and KOL activation
Board-ready 2-3 page Executive Summary quantifying risk, upside, and recommended next steps
Optional Add-Ons
Targeted Field Force Tune-Up sessions to embed new persistence messaging
Focused New Manager Coaching to help frontline leaders drive the right behaviors post-audit
Advanced Metabolic Launch Architecture Mandate
For companies planning or executing a high-stakes U.S. launch in advanced metabolic or obesity categories.
What We Do
Design end-to-end Launch Architecture: target patient and prescriber segmentation, access strategy, field model, channel prioritization, and governance.
Build a Retention Engine integrating titration and side-effect navigation, patient support, and loyalty constructs to reduce early drop-off.
Lead KOL and Narrative Strategy so your story is clinically credible, payer-relevant, and executable by real reps in real clinics.
Includes Talent Architecture & Squad Building for key roles, with our senior leaders personally vetting finalists and providing UEM Fit Scores.
Deliverables
Complete launch architecture documentation and governance framework
Retention Engine design with KPIs and pilot program structure
KOL stratification, message platform, and activation plan
Talent architecture with role archetypes, competency models, and vetted candidate slates
Optional Add-Ons
Ongoing New Manager Coaching for new or expanded districts
Quarterly Launch War Room facilitation to adjust tactics based on real-world performance
Bespoke micro-video modules ("how we sell this asset") for internal training
Talent Architecture & Squad Building
For U.S. and foreign firms that cannot afford to get their first wave of hires wrong.
What We Do
Define the role archetypes and competencies required for complex metabolic and obesity launches: clinical fluency, access savvy, persistence mindset, and compliance rigor.
Run Clinical Stress Tests -- live role-plays on real cardio-metabolic cases. If candidates cannot explain your label, persistence data, and safety profile in plain language, they do not move forward.
Behavioral and Culture Screens to catch the red flags generalist recruiters miss: blame-shifting, territory entitlement, compliance gray-zones, and low coachability.
Network-Level Reference Checks through a 30-year network of managers and physicians -- not generic reference calls.
Deliverables
Role archetype definitions and competency models for your specific launch
Small curated slate with structured UEM Fit Scores (0-100) and narrative risk flags
Candidate briefs with strengths, risks, and ideal role fit recommendations
Optional Add-Ons
New Manager Coaching for leaders inheriting or building those squads
Asset-specific "Advanced Metabolic Selling 101" video series for onboarding
Real-World Evidence & Outcomes Strategy
For companies that need to prove real-world value to payers, prescribers, and boards in a market where trial data alone no longer wins formulary position.
What We Do
Design a RWE generation strategy aligned to your payer and KOL narrative -- what evidence do you need, when, and from whom to win access decisions.
Map existing real-world data assets (claims, EMR, registry, patient support) and identify gaps that will stall reimbursement or formulary placement.
Build an outcomes framework linking clinical persistence metrics (6-month/12-month adherence, weight loss, A1C reduction) to economic value stories that payers and P&T committees require.
Develop a competitive evidence positioning plan showing where your RWE advantage vs. GLP-1 incumbents (Novo, Lilly) is strongest and how to exploit it.
Deliverables
RWE Strategy Playbook: evidence gaps, data source map, generation timeline, and budget
Payer-ready value dossier framework with persistence and outcomes benchmarks
Competitive evidence landscape showing where your asset has differentiation potential
Optional Add-Ons
HEOR study design consultation for post-launch RWE generation
Payer advisory board facilitation to pressure-test evidence narratives
Payer Value Strategy & Contracting
For companies facing the complex payer dynamics of GLP-1 and obesity categories -- prior authorization walls, step therapy barriers, carve-outs, and formulary exclusions.
What We Do
Conduct a payer landscape assessment across commercial, Medicare Part D, and Medicaid to identify the specific access barriers threatening your launch trajectory.
Design contracting strategy including value-based agreements, outcome-based pricing models, and risk-sharing frameworks tailored to metabolic and obesity therapeutics.
Build formulary defense and negotiation toolkits that your market access team can execute in real payer meetings -- not theoretical slide decks.
Model gross-to-net scenarios and rebate architectures to protect revenue while expanding covered lives in a category where payer skepticism is high.
Deliverables
Payer Access Strategy with tier-by-tier coverage targets and contracting roadmap
Value-based contracting templates with outcomes metrics, measurement methodology, and risk-sharing terms
Formulary negotiation toolkit with objection handling, clinical evidence cards, and economic value arguments
Optional Add-Ons
Mock payer negotiations with former PBM and health plan decision-makers
Quarterly payer landscape monitoring and contracting strategy refresh
Built by operators who have carried the bag
“Echelon identified where we were losing patients in the first 90 days and gave us a clear, executable Retention Engine. Within two quarters, early discontinuation improved in our pilot regions.”
James D., COO
“They gave us a practical launch blueprint, helped us structure our US entry model, and coached our leadership through decisions that would have taken months on our own.”
Karen M., CCO
“Echelon's interview stress tests and fit scoring completely changed how we hire. The difference in day-one readiness of our new hires has been obvious.”
Michael R., SVP Sales
A la carte add-ons
Available as standalone engagements or bundled with core services. Priced as discrete packages ($35-75K depending on scope).
New Manager Coaching
For first-time district/regional managers in metabolic and specialty categories. 3-6 virtual session packages with optional shadowing and call reviews.
Outcome: Shorten the time it takes a new manager to become effective at coaching complex metabolic selling and managing compliance.
Field Force Tune-Up
Short 1-2 half-day virtual engagements to pressure-test and sharpen how reps sell GLP-1, dual/triple, or obesity assets and handle payer and persistence objections.
Outcome: Immediate uplift in message quality and clinical credibility of your existing field force.
Launch War Room Facilitation
1-2 day structured working session with cross-functional leaders to walk through your Launch Architecture and Retention Engine with an Echelon senior leader as external stress tester.
Outcome: Identify blind spots and misalignments before they become expensive field-level problems.
Not sure which service fits?
Start with a 30-minute Launch Stress Test. We will diagnose where your launch is most exposed and recommend the right engagement model.
Schedule a Stress Test →